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View Full Version : Trenbolone and IGF-1 - synergy?


TheFollistatin
07-24-2006, 02:58 PM
After dong some research it looks like Tren has some kind of interaction with one's natural IGF-1 production or sensitivity.

Anyone stacked IGF-1 and Tren Ace? results? theories on how it's best stacked?

my theory: to build sensitivity to IGF-1 with Tren, stack the two, then use IGF-1 when receptors are built up from Tren and testicular function can be semi-normalized as a semi-mid-cycle-PCT.

1-6 Tren Ace 50mg ED
5-10 IGF-1 40mcg ED

Beside the question:

1-16 (some anabolic/low androgenic steroid...prob EQ.)
7-16 test?

pct: IGF-1 again for 4 weeks.

TheFollistatin
07-25-2006, 11:15 AM
OK, fine. Let me show you what I mean.

First is Big Cat:

'While this is a large contributor there is evidence that it mediates muscle growth by another pathway entirely2,3, namely the increasing of satellite cell sensitivity to an increase in IGF-1 (Insulin-Like growth factor 1) and FGF (Fibroblast growth factor). This would result in a much, much greater nutrient uptake and protein synthesis and explain why trenbolone is so much more potent in building lean muscle than other non-aromatizing, AR-mediated steroids like drostanolone and mesterolone"

Second is Mesomorphosis: (Bryan Haycock)

"In vitro have also shown that some androgens increase muscle satellite cells sensitivity to fibroblast growth factor and IGF-1.10 Remember that satellite cells are required for a muscle cell to grow. Bovine muscle satellite cells were able to fuse 20% more readily when treated with trenbolone and estradiol.11,12 One may surmise that it was not only the trenbolone but also the estradiol that was causing the significantly increased feed efficiency and muscle growth by way of increased GH and IGF-1 production both in the liver as well as in muscle cells. From these studies it is clear that IGF-1 is critical to get maximum anabolic activity from androgens. This means that androgens that increase GH production (i.e. those that aromatize to some degree) will most likely give you the greatest and most rapid gains in muscle mass."

So one would assume that for the greatest gains Test/Tren/IGF-1 stack would be the best bet by first increasing endogenous IGF-1 production and upgrading those IGF-1 receptors with androgenic compounds such as Tren and Test, then overlapping that with IGF-1. The use of a relatively safe anabolic compound such as EQ to 'lock in' those gains and keep appetite high may also be beneficial. Time off IGF-1 is taken with only EQ, then IGF-1 is used again to further lock in results and bring the testes back to full form with a 4 week cycle of IGF-1 as PCT.

So for a first time Tren user, but rather experienced AAS user:

1-6 Test prop / Tren Ace 50mg ED
4-9 IGF-1 40-80mcg ED. (AP?)
1-16 Equipoise 600mg? p/w
PCT (2 weeks off)
19-22 IGF-1

In my experience the use of IGF-1 in a cycle or for PCT helps retain gains immensely.
Choromium Pic. at 500mcg 2x per day, 300mg R-ALA ed, and a high Amino acid intake may enhance gains.

I suppose the question is, has anyone done cycles of IGF-1 with Tren and without tren and were the differences in gains much better?

Also, would you extend test use with the EQ when the Tren/Prop stage is over? without turning yourself into a pin cushion (switching to a longer ester), what ester would you use, how much, and at what week? 5? 6? 7? Perhaps Cypionate with its 2 week half life would be good to start at week 5 or 6.